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Claude D. Pepper Older Americans Independence Center

Established in 1991, the UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to maintain and restore the independence of older persons. The UCLA Center’s theme is "Inflammation, Aging, and Independence".

The UCLA OAIC conducts observational and interventional research on factors that contribute to increased inflammation in aging and its consequences. The OAIC aims to:

  1. Determine how inflammatory markers change with normal aging and with specific diseases and how these changes in inflammation affect diseases and outcomes related to independence;
  2. Link inflammatory markers to genetic and epigenetic profiles; and
  3. Develop and test interventions to reduce inflammatory burden and determine the effects of these interventions on health and functional outcomes.

UCLA OAIC Research Resource Cores

Data Acquisition and Analysis Core (DAAC)

Services provided:

  • Assistance to OAIC pilot, CDA, and RPS awardees with project planning: operation logistics and budget, analysis strategy selection and sample size and power calculations
  • Mentoring of junior researchers doing clinical research in aging
  • Support for analysis of previously collected data (Data Access Program) to address research questions related to aging and inflammation

Inflammatory Biology Core (IBC)

Consultations provided:

  • Intellectual support for the analysis of inflammatory biology in basic and clinical research on inflammatory biomarkers and mechanisms
  • Potential collaboration on study design, technical issues, biomarker assay selection/performance/interpretation for externally-funded projects
  • Referral to UCLA Social Genomics and Microarray cores for genomic assessments of inflammatory activity and its cellular impact
  • Referral to UCLA Flow Cytometry core for cell surface and/or intracellular phenotyping
  • Referral to UCLA Cousins Center for PNI for telomere length and telomerase assays

Funding Opportunities

Career Development Award and Research Project Support

Mentored Career Development Awards:

  • $25 K per year for up to 3 years
  • Individualized training programs
  • Requires mentors match ($25K)

Research Project Support (RPS)

  • Provides up to 2 years project support to postdoctoral and junior faculty with existing T, F, K or similar awards to add new aims relevant to inflammation and aging

Data Access Project (DAP)

  • Funding is available to support analysis projects that make use of existing data sets housed in the OAIC or data sets that senior or junior UCLA faculty have access to.
  • The award will fund an OAIC data analyst for 6-12 months to conduct the analysis.
  • Eligibility: Junior investigators (fellows, post-docs, or junior faculty) from any discipline in the Department of Medicine with an interest in inflammation and its effects on the health and well-being of older persons.

Rapid Pilot Funds

Rapid Grants Program provides funding for:

  • Small aging-related basic, clinical and health services research projects
  • Award sizes range from $1,000 to $10,000, dependent on scope of work
  • Eligible applicants include UCLA junior faculty members/advanced trainees with a senior faculty mentor, or UCLA senior faculty members who wish to use pilot funding to create a new area of aging-related emphasis in their work
  • "Rolling applications process" with rapid turnaround (1 to 2 months); funds must be expended by the end of the fiscal year in which they were awarded

UCLA OAIC General Questions