UCLA Geriatrics and Gerontology Research
|Claude D. Pepper Older Americans Independence Center|
Established in 1991, the UCLA Claude Pepper Older Americans Independence Center (OAIC) is designed to maintain and restore the independence of older persons. The UCLA Center's theme, "Preventing Disease and Disability in Vulnerable Populations: a Translational Approach" emphasizes research that extends across the full spectrum from T1 to T2 translational research. Within this theme, an important focus of the UCLA OAIC is on developing and understanding interventions that reduce inflammation.
We define basic sciences broadly, recognizing that biologic sciences (e.g., molecular biology and immunology), physical sciences (e.g., biomechanics), and social sciences (e.g., cost-effective analysis, behavioral theory) are all fundamentals upon which clinical interventions are derived and evaluated.
In the UCLA OAIC paradigm, basic biomedical research informs clinical research and clinical research informs basic biomedical research. Accordingly, the UCLA OAIC supports research that links these two types of research in both directions by 1) examining mechanisms underlying successful clinical interventions and 2) developing new basic science approaches that will lead to clinical interventions. In addition to this emphasis on T1 research, the UCLA OAIC has expanded its strategy and reach to include the second stage of translational research, T2. T2 research brings new knowledge into clinical practice and decision-making.
The Center stimulates scientific discovery through 4 Research Cores (Recruitment and Retention, Research Operations, Analysis and Cost-effectiveness, and Inflammatory Biology), a Pilot and Exploratory Studies Core, a Research Career Development Core, and a Leadership/Administrative Core. Research Cores provide 4 levels of support (consultation, short-term, ongoing, and partnership on new projects) for external projects and internal OAIC activities.
The purpose of the Pilot and Exploratory Studies Core is to promote innovative basic and clinical research, conducted by collaborating teams of junior and senior investigators through pilots and exploratory studies, that falls within the UCLA OAIC's research theme. Pilot funding generally starts July 1 and requests for proposal are announced in the fall. The OAIC also has a rapid pilot award mechanism with quick turnaround for small pilots or to obtain additional data for grant submissions. Requests for applications are generally announced in the winter.
The goal of the Research Career Development Core is to train junior faculty members to become future academic leaders in translational basic, clinical and health services research directed toward improving the independence of older persons. A related goal is to attract new faculty from various disciplines into aging research. The Career Development Award (CDA) program provides integrated training in translational mechanistic and outcomes research, and promotes faculty career development. CDA funding generally starts July 1 and requests for applications are announced in the fall.
Pilot and Exploratory Studies Core
Pilot Program provides funding for:
Rapid Grants Program provides funding for:
Mentored Career Development Awards:
• Consulting (e.g., few hours of advice, reading a paper or proposal)
• Support is provided for the use of services provided by the UCLA OAIC Research Cores. Up to $10,000 of such support may be requested per Core
Services Provided by the Research Cores
Analysis and Cost-Effectiveness Core (ACEC)
Inflammatory Biology Core (IBC)
Recruitment and Retention Core (RRC)
Research Operations Core (ROC)
UCLA OAIC General Questions
• Lucio Arruda - Administrator
National Pepper Center Website: www.peppercenter.org